ea0038s7.2 | The rise and rise of the FGFs in endocrinology | SFEBES2015
Kharitonenkov Alexei
, Agrawal Archita
, Li Pengyun
, DiMarchi Richard
, Perez-Tlive Diego
Fibroblast growth factor 21 (FGF21) is an emerging regulator of energy homeostasis and a novel target for the development of therapies to treat diabetes, cardiovascular disease, and obesity. FGF21 was discovered in an in vitro high throughput screen. It was later shown to have impressive metabolic pharmacology including glucose, lipid, and body weight lowering effects in a variety of animal models, including non-human primates. When tested clinically an FGF21-based an...